![]() Our ongoing research is aimed at understanding how Cdc25B activity is regulated and at identifying proteins that interact with Cdc25B to control its function. We have identified the dual specificity phosphatase, Cdc25B, as a key regulator of meiotic maturation in female mammals. Our research has focused on identifying key molecules that regulate meiosis in mammals. In a separate area of research we seek to understand another key aspect of germline differentiation, namely meiosis. These studies are aimed at understanding how genomic imprinting, karyotype and developmental potency may be affected by cell culture and how transplanted ES cells and EG cells behave upon transplantation. Finally, we are using models to determine key safety issues associated with stem cell transplantation. ![]() These pathways may be critical to understanding how to grow hES cells in very large scale as well as understanding why hES cells can become aneuploid in culture. We are using such techniques to carry out high throughput screens to identify pathways that regulate stem cell survival and proliferation of hES cells. Using factors that support clonal survival of hES cells we have improved methods for genetically modifying hES cells. A second major area of research is aimed at understanding the factors that control the survival of hES cells. Learning how to control stem cell potency may point to new methods of maintaining EG or ES cells in an undifferentiated state for a prolonged period of time, or avoid the tumorigenic potential of these cells when transplanted into animals. One aspect is the regulation of developmental potency within the mammalian germline and within pluripotent stem cells derived from germ cells (embryonic germ cells, or EG cells) and from early embryos (embryonic stem cells, or ES cells). Molecular Genetics of Germ Cell and Stem Cell Development – Our laboratory is interested in four critical aspects germ cell and stem cell biology. It's a roadmap of his past seen through fresh eyes, and a triumphant first step in this new chapter.Program Director, CIRM Training Grant II Principal Investigator, CIRM Shared Research Laboratory and Stem Cell Techniques Course Professor, Department of Developmental and Cell Biology Donovan has managed to create an album that is sonically nostalgic and modern at once, both soul-stirring and dripping with heartache. It's an album about learning and growing from lived experiences and reflecting on past failures in the interest of future successes. The songs are more reflective than bitter more nostalgic than sad. With This Better Be Good, Donovan spreads his wings, combining the plaintive soul of indie rock, the heartfelt sincerity of Americana, and the stirring studio pageantry of '70s singer-songwriters, drawing them together to explore more intimate depths.This Better Be Good is Donovan's most personal effort yet a loose concept record about the ups and downs of an ultimately doomed romance between two people. His previous releases spun expertly-crafted character sketches that earned plaudits from Paste Magazine, Consequence of Sound, American Songwriter, and more. ![]() After finding success and a dedicated fanbase with Seattle's All The Real Girls and his side project The Rose Petals (alongside Elijah Ocean), Donovan returns in 2022 with his first proper solo album, This Better Be Good. His perceptive songs span genres and feature narratives based on both real-life and fictitious characters, written with a contemplative heart. Peter Donovan is an astute musical storyteller. ![]()
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